I am currently using Linux Mint (after a long stint of using MX Linux) after learning it handles Nvidia graphics cards flawlessly, which I am grateful for. Whatever grief I have given Ubuntu in the past, I take it back because when they make something work, it is solid.
Anyways, like most distros these days, Flatpaks show up alongside native packages in the package manager / app store. I used to have a bias towards getting the natively packed version, but these days, I am choosing Flatpaks, precisely because I know they will be the latest version.
This includes Blender, Cura, Prusaslicer, and just now QBittorrent. I know this is probably dumb, but I choose the version based on which has the nicer icon.
I use flatpaks mostly. Flatpak dependencies (runtimes) are stored separately from the host system so and don’t bloat my system with unwanted libraries and binaries. App data and configs are stored separately and better organized. Everything runs in sanboxes. I use overrides extensively. All these are very convenient for me.