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Cake day: August 20th, 2023

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  • https://www.nbcnewyork.com/paris-2024-summer-olympics/olympics-boxing-imane-khalif-xy-chromosome-italian-boxer-quit/5662035/

    Look number one, whether or not she is xy has not been confirmed. It was reported by a Russian controlled organization only after she beat a Russian fighter, and they haven’t actually released their results or methods.

    Second, what the posted article is referring to, if she was indeed xy (which is just suspect Russian heresay at this point), is androgen insensitivity syndrome. Meaning she wouldn’t be able to derive benefit from testosterone anyways. This is also different from trans individuals on a number of levels. Though Russia of course sees it as beneficial both for smearing anyone that beats their own athletes, as well as stoking popular lgbt hatred in their own country.

    The only story here is Russia co opting international sports organizations for their own purposes once again, just like when they had state organized doping of their athletes that went all the way to the top involving the flipping FSB. Now they are also using it to try and spread fear and hate of trans individuals, even though it wouldn’t be trans in this case it would be intersex if what they said is true, and we have no actual confirmations that she is intersex anyway. I’ll believe it when an organization not controlled by Russia shows it (and even if they were correct it’s very likely she wouldn’t be deriving any advantages from it).

    https://www.washingtonpost.com/sports/olympics/2024/08/03/olympics-2024-khelif-russia-boxing/a7e9ff36-5191-11ef-9728-3037305a6b0f_story.html

    They’ve made similar unsubstantiated claims against another boxer. They still haven’t released any specifics of their testing, and they only made these claims after they claimed world championship titles in each case. What a coincidence.

    I doubt either of them is actually xy. This Russian boxing organization was banned by the international community for good reason.




  • Oh yes absolutely op’s x chromosome is expressed. I just meant unlike all the other chromosomes where in general both gene copies on both chromosomes are expressed, in xx individuals usually one of the x chromomes is inactivated and only one of them is being expressed at a time. The x chromosome has many essential genes. This is why we have x linked genetic diseases as well. Often xx individuals are just carriers or more mildly affected since they have two x chromosomes, and xy individuals are more severely affected since they have no backup copies of that gene.


  • Thank you for clarifying those misconceptions about what recessive and dominant are getting at. A gene isn’t really dominant or recessive. A phenotype (some trait in the organism like blue eyes or a certain disease) can be dominant or recessive though and results from changes in a gene. The same gene could have many different possible mutations, some with dominant effects, some with recessive effects, or some with no effects, depending on the change in the gene and the phenotype.

    To go further on that, many recessive diseases are because just one functional copy of many genes are fine from your body’s perspective. Many recessive diseases are due to loss of function of a gene or its protein product, a gene that for a variety of potential reasons no longer leads to a functional protein. Often your body can get by with just one working gene making protein, though both gene copies are generally always being transcribed and trying to be turned into functional protein.

    One big exception to this is the x chromosome. Males only have one x and have a y instead of a second x. The y is very tiny and has very few genes compared to the x, quite different from other chromosome pairs which generally just have copies of all the same genes on each other. Early in embryo development for xx individuals, one of the x chromosomes is generally inactivated and not expressed very much, otherwise xx individuals would have double the gene products of all those different genes compared to males, which the body is not expecting for x genes like it does for all the other genes that have a second copy.

    https://en.m.wikipedia.org/wiki/X-inactivation

    If you go even further you also get into the idea of penetrance. A gene codes for a protein, but that protein doesn’t exist in isolation, it interacts with lots of other proteins coded by other genes in the body, plus the environment. So for some genetic changes it might be a 100% chance at leading to a certain phenotype (like a disease or a specific trait), or it could be less, like only 70% or 30% chance or something of someone with that change getting that trait, even if it’s still “dominant” (meaning only one gene copy with that change is needed to express the trait).




  • Doctors are paid more, but still a small slice of healthcare costs. Doctors in the US working entirely for free would barely make a dent. All administrative costs, including doctors and nurses salaries, but also our bloated health care administration, add up to 8%. A lot of the extra administration costs are also things like all the staff needed just to interface with the giant mess of different payers including multiple private and government programs, all with different documentation and billing requirements.

    The insurance companies, pharmaceutical companies, medical device and equipment companies, and private equity owners of hospitals and practices who are all reaping windfall profits at the expense of patients love to direct the blame to doctors though.


  • This is bizarre, I looked and Rochester Minnesota has multiple high speed providers, including two that offer fiber.

    And the isp you have is a wireless isp that doesn’t even list Rochester as within its coverage area, they’re intended to serve more rural areas west of the city. On their map it gets close to but not quite in Rochester, but maybe they’re still able to access it (slowly) since it’s a wireless provider.

    I’m guessing this is a whoever owns your Airbnb problem rather than a Rochester Minnesota problem. I don’t understand why they would be paying for this rather than use any of the readily available high speed options there.


  • The Russian invasion of Afghanistan is just one chapter in an extensive history including genocide of Islamic peoples within its borders with many more recent events as well. Putin himself rose to power carpet bombing Chechnya. Even more recently, Russia literally going to Syria to attack Isis, where they still are stationed and fighting. Their efforts to keep Bashar Al Assad in power infuriated Isis. They also have their African forces recently assimilated from Wagner group attacking Islamic militants across Saharan Africa, some of which consider themselves branches of Isis. If “literally being attacked by them across the world as we speak right now” is not motive enough for them to attack back for you, I don’t know what would convince you. This isn’t even the first time Isis has claimed to attack Russia, there’s been a string of attacks from Isis going back to 2015.

    And Isis is opposed to the Taliban in Afghanistan and actively fighting them as well. I don’t know what you’re on about.






  • Creditors aren’t dumb, no way they’re going to accept this as a collateral. Even if they did have the ability to sell if needed (they don’t, it’s illiquid at the moment), unwinding $450 million in shares is going to take some time, and the sale itself is large enough it would affect the stock price itself. There’d be no good way of knowing how much stock you’d have to hold in the account to ensure that $450 million in cash could be extracted from it if needed.

    This isn’t just some small personal account with a line of credit that the creditor can make a maintenance/margin call on to ensure a certain collateral balance is maintained. This is a substantial percentage of the market cap of one single company with an extremely volatile stock based on near zero fundamentals, in a position that likely can’t be unwound without tanking its own value.

    Most likely thing Trump does in reality is work with a bank (who will accept real estate as collateral, unlike the bond companies) to get a letter of credit from a bank, and then bring the letter of credit to the bond company. This whole dog and pony show of “I can’t pay” is probably fake to try and see if he can convince the courts to delay his payment. Unless he truly does have no real equity in his properties like some people say. Or banks really are done with him. Will be interesting to hear what the independent court appointed monitor thinks about all of this. I wouldn’t be surprised though if Monday just before seizures could start Trump’s lawyers are like, jk we put these properties up as collateral like we could have done at any time in actuality, for a letter of credit, and used that to secure a bond. Rather than let NY state take control of them. I hope they do get seized by New York though.


  • What’s actually being traded right now is a small portion of the actual shares that will make up the new merged company. This dollar amount assumes that trump would be able to sell 60% of all stock in the company (which is much more than is available to trading right now), without sending the stock price right into the ground. That’s just not going to happen.

    This lockup period prevents him from selling for 6 months to prevent the share price from tanking just after the merger from insider selling, but the board could decide to remove that restriction so he could start offloading shares. Even if they don’t, when we get closer to lockup expiration I’m guessing the shares will likely begin tanking in anticipation of Trump doing this. He’d be dumb not to try and offload shares, the company is insanely overvalued.




  • It would delay things further unfortunately, but this is so egregiously wrong and in such a long list of mistakes and/or illegitimate moves meant to provide cover for Trump, I don’t think there’s any recourse but for Jack Smith to move to have her taken off the case. Even more when you consider her involvement prior to these charges when she got improperly involved with the search warrant bussiness before a higher court told her off and dismissed the whole thing. Shame she’s the one assigned to the strongest and least legally controversial criminal case against him.