So, I assume that if you put 100 people on a spaceship and sent them to wherever, they’d get very inbred in a few generations. How many people would you need for this to not happen, accounting for the fact that there will eventually be people who are infertile or die before having children?


In a Sci fi context where we have generation ships, I would add frozen sperm/eggs to the equation and even artificial womb. In like a 100kg package you can store a lot of genetic material. That’s pretty fucked up (and a nice writing prompt) but definitely doable.
At this point the question is also cultural what is the minimum amount of person to keep a population able to maintain a large ship over centuries and produce enough food
i don’t think it’s that fucked up to have everyone with a womb be a surrogate mother, you’d just have to select people who are okay with it. There’s nothing wrong with being a surrogate, it’s basically just adoption except you get to give birth to the child.