So, I assume that if you put 100 people on a spaceship and sent them to wherever, they’d get very inbred in a few generations. How many people would you need for this to not happen, accounting for the fact that there will eventually be people who are infertile or die before having children?
i don’t think it would even be that much of a concern, really. Not only can one person have multiple children (so you can do one surrogate and one genetically yours), but there are plenty of people who’d just be happy they get to give birth to their child and couldn’t care less about genes.